Layer shifting is due to incorrect alignment of the X-Y axis. Check the Wiki to find an alignment procedure.
Use Cura. It slices a lot better and faster than Slic3r.
This is because you’re extruding too much filament.
Use these parameters :
For PLA t°=190° - flow 75%
Retraction 3 mm at 120mm/s.
Use a wall thickness = multiples of 0.3 (0.3, 0.6, 0.9 etc).
I’ve noticed that the problem comes when I print in the center of the bed. If I put the piece displaced from the center, the head doesn’t “jump” and the printing is correct.